Further investigations on the action of detergents on the eye.

It is well known that the incorporation of wetting agents in drug solutions for local application enhances the penetration of the drug into the tissues (McKee et al., 1943; Bellows and Gutman, 1943; Trim and Alexander, 1946). Ginsburg and Robson (1945) have shown that when dodecyl sodium sulphate is incorporated in solutions of sodium sulphacetamide applied to the cornea, the increase in penetration is due to an action of the detergent on the corneal epithelium. The action of the detergents on the eye has been further investigated and the results are described in the present communication.